“DARMIS” Study

International multicenter prospective surveillance monitoring of antimicrobial resistance of uropathogens causing community-acquired UTI in different subsets of patients

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Organisers

  • Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC)
  • Russian Society of Urologists
  • Institute of Antimicrobial Chemotherapy of Smolensk State Medical University (IAC)

Annotation

Dataset on antibiotic resistance profile of community-acquired uropathogens isolated from urine samples of:

  • adults with symptomatic UTI (cystitis, pyelonephritis);
  • children and adolescents under 18 years with symptomatic UTI (cystitis, pyelonephritis);
  • pregnant women with symptomatic UTI (cystitis and pyelonephritis) and asymptomatic bacteriuria.

The study was conducted in two periods:

  • DARMIS 2009-2011: 28 centers, 20 cities
    • Russia: Voronezh, Yekaterinburg, Irkutsk, Kazan, Krasnodar, Moscow, Omsk, Rostov-on-Don, Samara, St. Petersburg, Seversk, Smolensk, Surgut, Tomsk, Tyumen, Ufa, Chelyabinsk, Yakutsk;
    • Belarus: Gomel;
    • Kazakhstan: Karaganda.
  • DARMIS 2017-2018: 33 centers, 26 cities
    • Russia: Bratsk, Voronezh, Yekaterinburg, Irkutsk, Yoshkar-Ola, Kazan, Kirov, Krasnodar, Nizhnevartovsk, Novokuznetsk, Novosibirsk, Omsk, Rostov-on-Don, Samara, St. Petersburg, Seversk, Smolensk, Surgut, Tolyatti, Tomsk, Ulyanovsk, Chelyabinsk, Yakutsk, Yaroslavl;
    • Belarus: Gomel;
    • Kazakhstan: Karaganda.
  • DARMIS-2023 (2023): 30 centers, 22 cities
    • Russia: Belgorod, Voronezh, Yoshkar-Ola, Kazan, Kirov, Moscow, Novosibirsk, Petrozavodsk, Rostov-on-Don, St. Petersburg, Seversk, Simferopol, Smolensk, Tver, Tolyatti, Ulan-Ude, Ulyanovsk, Khabarovsk, Chelyabinsk, Yakutsk, Yaroslavl;
    • Kazakhstan: Karaganda.

Antibiotic Susceptibility Testing

Minimum inhibitory concentrations (MICs) of antibiotics were determined by reference broth microdilution method (BMD) in Mueller-Hinton broth according to ISO 20776-1:2006 at the Central Laboratory of the Institute of Antimicrobial Chemotherapy of Smolensk State Medical University (IAC)

Interpretation of MICs

Clinical susceptibility categories are assigned according to the current versions of the Russian guidelines “Determination of the susceptibility of microorganisms to antimicrobial drugs” (2024-02) and the criteria of the European Committee on Antimicrobial Susceptibility Testing (EUCAST v. 14.0, 2024). For quality control of susceptibility testing the strains Escherichia coli ATCC®25922, Escherichia coli ATCC®35218, Staphylococcus aureus ATCC®29213, Enterococcus faecalis ATCC®29212 and Pseudomonas aeruginosa ATCC®27853 were used.

DARMIS Study Group

  • Agapova E.D. (Irkutsk)
  • Ankirskaya A.S. (Moscow)
  • Elokhina E.V. (Omsk)
  • Galeeva O.P. (Kazan)
  • Gudkova L.V. (Tomsk)
  • Gumenetskiy D.V. (Chelyabinsk)
  • Khasanova S.G. (Ufa)
  • Khokhlyavina R.M. (Tyumen)
  • Kogan M.I. (Rostov-on-Don)
  • Kozlova L.V. (Smolensk)
  • Lavrinenko A.V. (Karaganda, Kazakhstan)
  • Loginov Yu.A. (Smolensk)
  • Malev I.V. (Smolensk)
  • Morozov M.V. (Smolensk)
  • Moskvitina E.N. (Seversk)
  • Multykh I.G. (Krasnodar)
  • Naboka Yu.L. (Rostov-on-Don)
  • Nastausheva T.L. (Voronezh)
  • Nikolskaya I.G. (Moscow)
  • Ortenberg E.A. (Tyumen)
  • Oskina E.A. (Samara)
  • Palagin I.S. (Smolensk)
  • Perevalova E.Yu. (Yekaterinburg)
  • Polukhina O.V. (St. Petersburg)
  • Rozanova S.M. (Yekaterinburg)
  • Safina A.I. (Kazan)
  • Savicheva A.M. (St. Petersburg)
  • Sekhin S.V. (Smolensk)
  • Skalskiy S.V. (Omsk)
  • Tapalskiy D.V. (Gomel, Belarus)
  • Tatarinova O.V. (Yakutsk)
  • Trapeznikova B.V. (Surgut)
  • Valiullina I.R. (Kazan)
  • Zhestkov A.V. (Samara)
  • Zulkarneev R.Kh. (Ufa)

DARMIS-2018 Study Group

  • Amineva P.G. (Yekaterinburg)
  • Becker G.G. (Novosibirsk)
  • Bulkin A.N. (St. Petersburg)
  • Bykonya S.A. (Tomsk)
  • Chastoedova A.N. (Kirov)
  • Domanskaya O.V. (Novokuznetsk)
  • Elokhina E.V. (Omsk)
  • Ershova M.G. (Yaroslavl)
  • Ivanova I.A. (Yoshkar-Ola)
  • Khaidarshina N.E. (Chelyabinsk)
  • Khusnutdinova T.A. (St. Petersburg)
  • Kogan M.I. (Rostov-on-Don)
  • Kulchavenya E.V. (Novosibirsk)
  • Lavrinenko A.V. (Karaganda, Kazakhstan)
  • Lyamin A.V. (Samara)
  • Malev I.V. (Smolensk)
  • Malyavin A.I. (Ulyanovsk)
  • Martyanova N.M. (Tolyatti)
  • Moskvitina E.N. (Seversk)
  • Mutin M.Yu. (Bratsk)
  • Naboka Yu.L. (Rostov-on-Don)
  • Nikiforovskaya N.N. (Smolensk)
  • Palagin I.S. (Smolensk)
  • Plugin P.S. (Novosibirsk)
  • Popova L.D. (Omsk)
  • Portnyagina U.S. (Yakutsk)
  • Shamaeva S.Kh. (Yakutsk)
  • Shipitsyna E.V. (St. Petersburg)
  • Shirokova T.M. (Kirov)
  • Sidorova R.K. (Ulyanovsk)
  • Strebkova V.V. (Voronezh)
  • Sukhoreva M.V. (Irkutsk)
  • Tapalsky D.V. (Gomel, Belarus)
  • Valiullina I.R. (Kazan)
  • Varganova A.N. (Surgut)
  • Varibrus E.V. (Krasnodar)
  • Vasilyeva I.R. (Nizhnevartovsk)
  • Vetokhina A.V. (Irkutsk)
  • Volkovskaya I.V. (Tomsk)
  • Zhestkov A.V. (Samara)

DARMIS-2023 Study Group

  • Andronova T.I. (Simferopol),
  • Akhremenko Y.A., Portnyagina U.S. (Yakutsk),
  • Belashova M.A. (Belgorod),
  • Burasova E.G. (Ulan-Ude),
  • Dolzhenko E.V., Khamtsova Zh.V. (Tver),
  • Eremeeva A.V. (Moscow),
  • Ershova M.G. (Yaroslavl),
  • Ibishev Kh.S., Naboka Yu.L. (Rostov-on-Don),
  • Ivanova I.A. (Yoshkar-Ola),
  • Kataeva E.I. (Chelyabinsk),
  • Kotov S.V., Pulbere S.A. (Moscow),
  • Kuzmin I.V. (Saint Petersburg),
  • Lavrinenko A.V. (Karaganda, Kazakhstan),
  • Lupyreva E.G. (Ulan-Ude),
  • Malyavin A.I., Sidorova R.K. (Ulyanovsk),
  • Mikhaylichenko A.O. (Khabarovsk),
  • Momotova A.A., Shirokova T.M. (Kirov),
  • Moskvitina E.N. (Seversk),
  • Nastausheva T.L. (Voronezh),
  • Nikitina I.V. (Novosibirsk),
  • Palagin I.S. (Smolensk),
  • Petrov S.B., Slesarevskaya M.N. (St. Petersburg),
  • Petrova L.V. (Moscow),
  • Plugin P.S. (Novosibirsk),
  • Popov S.V., Zhukov V.A. (Moscow),
  • Savicheva A.M., Khusnutdinova T.A. (St. Petersburg),
  • Shamaeva S.Kh., Portnyagina U.S. (Yakutsk),
  • Sholomova L.A. (Tolyatti),
  • Sukhorukova M.V. (Moscow),
  • Valiullina I.R. (Kazan),
  • Vityazeva V.P., Zlobina K.A., Zaripova Yu.R. (Petrozavodsk).

Coordinator

Ivan S. Palagin

ivan.palagin@gmail.com

Publications

  1. R.S. Kozlov, I.S. Palagin, N.V. Ivanchik, I.V. Trushin, A.V. Dekhnich, M.V. Edelstein, T.S. Perepanova, “DARMIS-2023” Study Group. National monitoring of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter epidemiological study “DARMIS-2023”. KMAKH 2024; 26(3): 328-337.
    cmac-journal.ru
  2. I.S. Palagin, M.V. Sukhorukova, A.V. Dekhnich, M.V. Edelstein, T.S. Perepanova, R.S. Kozlov, “DARMIS-2018” Study Group. Current state of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia, Belarus and Kazakhstan: results of the international multicenter study “DARMIS-2018”. Urology 2020; 1: 19-31.
    10.18565/urology.2020.1.19-31
  3. I.S. Palagin, M.V. Sukhorukova, A.V. Dekhnich, M.V. Edelstein, T.S. Perepanova, R.S. Kozlov, “DARMIS-2018” Study Group. Antimicrobial resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter study “DARMIS-2018”. KMAKH 2019; 21 (2): 134-146.
    10.36488/cmac.2019.2.134-146
  4. I.S. Palagin, M.V. Sukhorukova, A.V. Dekhnich, M.V. Edelstein, A.V. Grinev, T.S. Perepanova, R.S. Kozlov, DARMIS Study Group. Complicated community-acquired urinary tract infections in adult patients in Russia. KMAKH 2014; 16 (1): 39-56.
    cmac-journal.ru
  5. I.S. Palagin, M.V. Sukhorukova, A.V. Dekhnich, M.V. Edelstein, A.N. Shevelev, A.V. Grinev, T.S. Perepanova, R.S. Kozlov, “DARMIS” Study Group. Current state of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia: DARMIS Study (2010-2011). KMAKH 2012; 14 (4): 280-302.
    cmac-journal.ru
  6. T.S. Perepanova, R.S. Kozlov, A.V. Dekhnich, I.S. Palagin, A.N. Shevelev, E.M. Volkova, D.K. Egamberdiev. Choice of antimicrobial drugs in urinary infections. Urology 2012; 2: 4-8.
    cyberleninka.ru