DARMIS 2009-2011 & 2017-2018

International multicenter prospective surveillance study of antimicrobial resistance of uropathogens causing community-acquired UTI in different subsets of patients

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Organisers

  • Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy (IACMAC)
  • Russian Society of Urologists

Annotation

This dataset presents the data on antibiotic resistance of community-acquired uropathogens isolated from midstream urine samples of:

  • adults with symptomatic UTI (cystitis, pyelonephritis);
  • children and adolescents under 18 years with symptomatic UTI (cystitis, pyelonephritis);
  • pregnant women with symptomatic UTI (cystitis and pyelonephritis) and asymptomatic bacteriuria.

The study was conducted in two periods:

  • DARMIS 2009-2011: 28 centers, 20 cities
    • Russia: Voronezh, Yekaterinburg, Irkutsk, Kazan, Krasnodar, Moscow, Omsk, Rostov-on-Don, Samara, St. Petersburg, Seversk, Smolensk, Surgut, Tomsk, Tyumen, Ufa, Chelyabinsk, Yakutsk;
    • Belarus: Gomel;
    • Kazakhstan: Karaganda.
  • DARMIS 2017-2018: 34 centers, 26 cities
    • Russia: Bratsk, Voronezh, Yekaterinburg, Irkutsk, Yoshkar-Ola, Kazan, Kirov, Krasnodar, Nizhnevartovsk, Novokuznetsk, Novosibirsk, Omsk, Rostov-on-Don, Samara, St. Petersburg, Seversk, Smolensk, Surgut, Tolyatti, Tomsk, Ulyanovsk, Chelyabinsk, Yakutsk, Yaroslavl;
    • Belarus: Gomel;
    • Kazakhstan: Karaganda.

Antibiotic Susceptibility Testing

Minimum inhibitory concentrations (MICs) of antibiotics were determined by reference broth microdilution method (BMD) in Mueller-Hinton broth according to ISO 20776-1:2006 at the Central Laboratory of the Institute of Antimicrobial Chemotherapy (IAC), Smolensk State Medical University (SSMU)

Interpretation of MICs

Clinical susceptibility categories were assigned according to the European Committee on Antimicrobial Susceptibility Testing (EUCAST) MIC Clinical breakpoints v.10.0 (http://www.eucast.org/clinical_breakpoints/)

DARMIS 2009-2011 Study Group

  • Agapova E.D. (Irkutsk)
  • Ankirskaya A.S. (Moscow)
  • Elokhina E.V. (Omsk)
  • Galeeva O.P. (Kazan)
  • Gudkova L.V. (Tomsk)
  • Gumenetskiy D.V. (Chelyabinsk)
  • Khasanova S.G. (Ufa)
  • Khokhlyavina R.M. (Tyumen)
  • Kogan M.I. (Rostov-on-Don)
  • Kozlova L.V. (Smolensk)
  • Lavrinenko A.V. (Karaganda, Kazakhstan)
  • Loginov Yu.A. (Smolensk)
  • Malev I.V. (Smolensk)
  • Morozov M.V. (Smolensk)
  • Moskvitina E.N. (Seversk)
  • Multykh I.G. (Krasnodar)
  • Naboka Yu.L. (Rostov-on-Don)
  • Nastausheva T.L. (Voronezh)
  • Nikolskaya I.G. (Moscow)
  • Ortenberg E.A. (Tyumen)
  • Oskina E.A. (Samara)
  • Palagin I.S. (Smolensk)
  • Perevalova E.Yu. (Yekaterinburg)
  • Polukhina O.V. (St. Petersburg)
  • Rozanova S.M. (Yekaterinburg)
  • Safina A.I. (Kazan)
  • Savicheva A.M. (St. Petersburg)
  • Sekhin S.V. (Smolensk)
  • Skalskiy S.V. (Omsk)
  • Tapalskiy D.V. (Gomel, Belarus)
  • Tatarinova O.V. (Yakutsk)
  • Trapeznikova B.V. (Surgut)
  • Valiullina I.R. (Kazan)
  • Zhestkov A.V. (Samara)
  • Zulkarneev R.Kh. (Ufa)

DARMIS 2017-2018 Study Group

  • Amineva P.G. (Yekaterinburg)
  • Becker G.G. (Novosibirsk)
  • Bulkin A.N. (St. Petersburg)
  • Bykonya S.A. (Tomsk)
  • Chastoedova A.N. (Kirov)
  • Domanskaya O.V. (Novokuznetsk)
  • Elokhina E.V. (Omsk)
  • Ershova M.G. (Yaroslavl)
  • Ivanova I.A. (Yoshkar-Ola)
  • Khaidarshina N.E. (Chelyabinsk)
  • Khusnutdinova T.A. (St. Petersburg)
  • Kogan M.I. (Rostov-on-Don)
  • Kulchavenya E.V. (Novosibirsk)
  • Lavrinenko A.V. (Karaganda, Kazakhstan)
  • Lyamin A.V. (Samara)
  • Malev I.V. (Smolensk)
  • Malyavin A.I. (Ulyanovsk)
  • Martyanova N.M. (Tolyatti)
  • Moskvitina E.N. (Seversk)
  • Mutin M.Yu. (Bratsk)
  • Naboka Yu.L. (Rostov-on-Don)
  • Nikiforovskaya N.N. (Smolensk)
  • Palagin I.S. (Smolensk)
  • Plugin P.S. (Novosibirsk)
  • Popova L.D. (Omsk)
  • Portnyagina U.S. (Yakutsk)
  • Shamaeva S.Kh. (Yakutsk)
  • Shipitsyna E.V. (St. Petersburg)
  • Shirokova T.M. (Kirov)
  • Sidorova R.K. (Ulyanovsk)
  • Strebkova V.V. (Voronezh)
  • Sukhoreva M.V. (Irkutsk)
  • Tapalsky D.V. (Gomel, Belarus)
  • Valiullina I.R. (Kazan)
  • Varganova A.N. (Surgut)
  • Varibrus E.V. (Krasnodar)
  • Vasilyeva I.R. (Nizhnevartovsk)
  • Vetokhina A.V. (Irkutsk)
  • Volkovskaya I.V. (Tomsk)
  • Zhestkov A.V. (Samara)

Coordinator

Ivan S. Palagin

Research fellow

Institute of Antimicrobial Chemotherapy (IAC),
Smolensk State Medical University (SSMU)

ivan.palagin@gmail.com

Institute of Antimicrobial Chemotherapy

Publications

  1. I.S. Palagin, M.V. Sukhorukova, A.V. Dekhnich, M.V. Edelstein, T.S. Perepanova, R.S. Kozlov, “DARMIS-2018” Study Group. Current state of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia, Belarus and Kazakhstan: results of the international multicenter study “DARMIS-2018”. Urology 2020; 1: 19-31.
    10.18565/urology.2020.1.19-31
  2. I.S. Palagin, M.V. Sukhorukova, A.V. Dekhnich, M.V. Edelstein, T.S. Perepanova, R.S. Kozlov, “DARMIS-2018” Study Group. Antimicrobial resistance of pathogens causing community-acquired urinary tract infections in Russia: results of the multicenter study “DARMIS-2018”. KMAKH 2019; 21 (2): 134-46.
    10.36488/cmac.2019.2.134-146
  3. I.S. Palagin, M.V. Sukhorukova, A.V. Dekhnich, M.V. Edelstein, A.V. Grinev, T.S. Perepanova, R.S. Kozlov, DARMIS Study Group. Complicated community-acquired urinary tract infections in adult patients in Russia. KMAKH 2014; 16 (1): 39-56.
    cmac-journal.ru
  4. I.S. Palagin, M.V. Sukhorukova, A.V. Dekhnich, M.V. Edelstein, A.N. Shevelev, A.V. Grinev, T.S. Perepanova, R.S. Kozlov, “DARMIS” Study Group. Current state of antibiotic resistance of pathogens causing community-acquired urinary tract infections in Russia: DARMIS Study (2010-2011). KMAKH 2012; 14 (4): 280-302.
    cmac-journal.ru
  5. T.S. Perepanova, R.S. Kozlov, A.V. Dekhnich, I.S. Palagin, A.N. Shevelev, E.M. Volkova, D.K. Egamberdiev. Choice of antimicrobial drugs in urinary infections. Urology 2012; 2: 4-8.
    cyberleninka.ru