The main gram-negative bacterial pathogens recovered from cystic fibrosis patients
The cross-sectional study in Russia
- Pirogov Russian National Research Medical University
- Samara State Medical University
- Filatov Municipal Clinical Hospital
- Morozov City Children’s Clinical Hospital
The main gram-negative cystic fibrosis bacterial pathogens include Pseudomonas aeruginosa, Achromobacter spp., Burkholderia cepacia complex and Stenotrophomonas maltophilia. In this project, the results of antibiotic susceptibility testing of the main gram-negative cystic fibrosis bacterial pathogens recovered from cystic fibrosis patients in Russia are presented.
In January – February 2020, respiratory tract samples from 170 cystic fibrosis patients (5% of all cystic fibrosis patients in Russia) from 42 regions were analyzed. The detected main gram-negative cystic fibrosis bacterial pathogens (P. aeruginosa, Achromobacter spp., Burkholderia cepacia complex and S. maltophilia) were studied.
Antibiotic susceptibility testing
Minimum inhibitory concentrations of antibacterial agents were determined using broth microdilution method. The results were interpreted according to Clinical and Laboratory Standards Institute (CLSI, 2020) criteria.
Bocharova Yu.A., Savinova T.A., Lyamin A.V., Kondratenko O.V., Fedorova N.I., Semykin S.Yu., Polikarpova S.V., Zhilina S.V., Chaplin A.V., Korostin D.O., Mayansky N.A., Chebotar I.V.
The study was supported by the Russian Science Foundation (Project ID 20-15-00235).
Senior researcher, laboratory of molecular microbiology,
Pirogov Russian National Research Medical University